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irreparable (adj) not able to be set right; too bad to be put right.
Irreparable loss is such a severe loss that it cannot be made up. Irreparable damage is a permanent damage and cannot be set right. An irreparable harm is a harm that cannot be healed or repaired.
- The disease that he contracted in his thirtieth year caused an irreparable harm to his health. He never recovered permanently from it, in spite of the best efforts of the doctors.
- Jameson's prestige has suffered an irreparable damage, because of his sonís disgraceful record as a drunken young man, and his disreputable contacts. Jameson is depressed that he can never regain his prestige.