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profound (adj) strong/great/deep [of feeling. Knowledge, thought. Etc.].
You have profound respect for someone if you have great respect for them. Your feeling of sorrow is profound if you feel it strongly. You have a profound understanding of something if you understand it completely. Profound regret is deeply felt regret. A profound thinker is one who can think and understand things very well.
- The profound sorrow he felt at the death of Abraham Lincoln inspired poet Longfellow to write the poem ‘O Captain, My Captain.’
- Ramanujan, the Indian mathematician of the last century had profound knowledge of the theory of numbers. His discoveries and theories commanded profound respect from such great mathematicians of his time as Hardy.